The Association Between Neural Biomarkers and Olfactory Dysfunction in the Prodromal Stage of Parkinson's Disease: A Systematic Review
کد: G-1843
نویسندگان: Zohreh Ganji ℗, Farzane Nikparast, Naser Shoeibi, Ali Shoeibi, Hoda Zare *
زمان بندی: زمان بندی نشده!
برچسب: پردازش سیگنال های پزشکی
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Background: Parkinson’s disease (PD) is preceded by a prolonged prodromal phase marked by non-motor symptoms such as olfactory dysfunction (OD). Early identification of at-risk individuals remains challenging due to the lack of validated biomarkers. This systematic review evaluates the association between neural biomarkers and OD in prodromal PD, focusing on diagnostic accuracy and clinical utility. Methods: Following PRISMA guidelines, we searched PubMed, Scopus, Web of Science, and Embase (2000–2025) for studies assessing neural biomarkers (neuroimaging, molecular, genetic) and OD in prodromal PD. Risk of bias was evaluated using the Newcastle-Ottawa Scale. Results: Twenty-four studies (n=3721) met inclusion criteria. Analysis of DAT-SPECT imaging revealed significant deficits in striatal dopamine transporter binding in individuals with OD who later developed PD [Hazard Ratio (HR) 7.3, 95% CI 4.1–12.9, p0.001]. Reduced striatal binding correlated with OD severity (r=-0.53, p=0.002). Skin and CSF α-synuclein aggregates, measured by RT-QuIC, showed high specificity (89%, 95% CI: 82–94%) for prodromal PD. Genetic analyses indicated that LRRK2 G2019S carriers had higher OD prevalence (55% vs. 36%, p=0.0003) and significant DAT deficits. Combining DAT-SPECT and olfactory testing substantially improved diagnostic accuracy [Area Under the Curve (AUC)=0.88]. Conclusion: Olfactory dysfunction in prodromal PD is strongly linked to nigrostriatal degeneration, α-synuclein pathology, and genetic susceptibility. Multimodal biomarker panels, particularly combining DAT imaging and olfactory testing, enhance early diagnosis and risk stratification. Standardization of protocols and longitudinal validation are critical for clinical translation.
کلمات کلیدی
Parkinson's Disease, Olfactory Dysfunction, Neural Biomarkers
